Iron doped ?-Tricalcium phosphate: Synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation.

Title Iron doped ?-Tricalcium phosphate: Synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation.
Authors R.Kishore Singh; M. Srivastava; N.K. Prasad; S. Awasthi; A. Dhayalan; S. Kannan
Journal Mater Sci Eng C Mater Biol Appl
DOI 10.1016/j.msec.2017.04.130
Abstract

The ability of ?-Tricalcium phosphate [?-TCP, ?-Ca3(PO4)2] to host iron at its structural lattice and its associated magnetic susceptibility, hyperthermia effect, biocompatibility and mechanical characteristics is investigated. The studies revealed the ability of ?-Ca3(PO4)2 to host 5.02mol% of Fe(3+) at its Ca(2+)(5) site. Excess Fe(3+) additions led to the formation of trigonal Ca9Fe(PO4)7 and moreover a minor amount of CaFe3(PO4)3O crystallization was also observed. A gradual increment in the iron content at ?-Ca3(PO4)2 results in the simultaneous effect of pronounced hyperthermia effect and mechanical stability. However, the presence of CaFe3(PO4)3O contributes for the reduced hyperthermia effect and mechanical stability of iron substituted ?-Ca3(PO4)2. Haemolytic tests, cytotoxicity tests and ALP gene expression analysis confirmed the biocompatibility of the investigated systems.

Citation R.Kishore Singh; M. Srivastava; N.K. Prasad; S. Awasthi; A. Dhayalan; S. Kannan.Iron doped ?-Tricalcium phosphate: Synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation.. Mater Sci Eng C Mater Biol Appl. 2017;78:715726. doi:10.1016/j.msec.2017.04.130

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