Novel chitosan-sulfonated chitosan-polycaprolactone-calcium phosphate nanocomposite scaffold.

Title Novel chitosan-sulfonated chitosan-polycaprolactone-calcium phosphate nanocomposite scaffold.
Authors A. Ghaee; J. Nourmohammadi; P. Danesh
Journal Carbohydr Polym
DOI 10.1016/j.carbpol.2016.10.023

New bioactive nanocomposite scaffolds from chitosan, sulfonated chitosan, and poly(?-caprolactone) nanofibers were prepared. In this study, sulfonated chitosan was prepared using chlorosulfonic acid and combined with chitosan in order to improve the bioactivity of chitosan-based scaffolds. Meanwhile, different amounts of chopped-hydrophilic PCL nanofibers were incorporated into the fabricated scaffold in order to mimic extracellular matrix-like structure. In the end, apatite formed on/in the composite scaffolds through alternate dipping in calcium and phosphate rich solutions. The morphology, apatite forming ability, and mechanical properties of the scaffolds were evaluated. The results indicated that larger pore sizes, higher porosity and apatite deposition are obtained as a result of adding more PCL nanofibers. Contrary to the effects of increased pore size, addition of PCL nanofibers enhanced the mechanical properties. Cell culture experiments with osteoblast-like cells on the scaffolds demonstrated that incorporation of PCL nanofibers into the fabricated scaffolds improves cell viability and attachment.

Citation A. Ghaee; J. Nourmohammadi; P. Danesh.Novel chitosan-sulfonated chitosan-polycaprolactone-calcium phosphate nanocomposite scaffold.. Carbohydr Polym. 2017;157:695703. doi:10.1016/j.carbpol.2016.10.023

Related Elements


See more Calcium products. Calcium (atomic symbol: Ca, atomic number: 20) is a Block S, Group 2, Period 4 element with an atomic weight of 40.078. The number of electrons in each of Calcium's shells is [2, 8, 8, 2] and its electron configuration is [Ar]4s2. Calcium Bohr ModelThe calcium atom has a radius of 197 pm and a Van der Waals radius of 231 pm. Calcium was discovered and first isolated by Sir Humphrey Davy in 1808. It is the fifth most abundant element in the earth's crust and can be found in minerals such as dolomite, gypsum, plagioclases, amphiboles, pyroxenes and garnets. In its elemental form, calcium has a dull gray-silver appearance. Calcium is a reactive, soft metal that is a member of the alkaline earth elements. Elemental CalciumIt frequently serves as an alloying agent for other metals like aluminum and beryllium, and industrial materials like cement and mortar are composed of calcium compounds like calcium carbonate. It is also an biologically essential substance found in teeth, bones, and shells. The name "calcium" originates from the Latin word "calics," meaning lime.


Phosphorus Bohr ModelSee more Phosphorus products. Phosphorus (atomic symbol: P, atomic number: 15) is a Block P, Group 15, Period 3 element. The number of electrons in each of Phosphorus's shells is 2, 8, 5 and its electronic configuration is [Ne] 3s2 3p3. The phosphorus atom has a radius of and its Van der Waals radius is Phosphorus is a highly-reactive non-metallic element (sometimes considered a metalloid) with two primary allotropes, white phosphorus and red phosphorus its black flaky appearance is similar to graphitic carbon. Compound forms of phosphorus include phosphates and phosphides. Phosphorous was first recognized as an element by Hennig Brand in 1669 its name (phosphorus mirabilis, or "bearer of light") was inspired from the brilliant glow emitted by its distillation.

Related Forms & Applications