Single-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging.

Title Single-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging.
Authors I. Kami?ska; D. Elbaum; B. Sikora; P. Kowalik; J. Mikulski; Z. Felcyn; P. Samol; T. Wojciechowski; R. Minikayev; W. Paszkowicz; W. Zaleszczyk; M. Szewczyk; A. Konopka; G. Gruze?; M. Pawlyta; M. Donten; K. Ciszak; K. Zajdel; M. Frontczak-Baniewicz; P. St?pie?; M. ?api?ski; G. Wilczy?ski; K. Fronc
Journal Nanotechnology
DOI 10.1088/1361-6528/aa9974
Abstract

Nanostructures as color-tunable luminescent markers have become major, promising tools for bioimaging and biosensing. In this paper separated molybdate/Gd2O3 doped rare earth ions (erbium, Er3+ and ytterbium, Yb3+) core-shell nanoparticles (NPs), were fabricated by a one-step homogeneous precipitation process. Emission properties were studied by cathodo- and photoluminescence. Scanning electron and transmission electron microscopes were used to visualize and determine the size and shape of the NPs. Spherical NPs were obtained. Their core-shell structures were confirmed by x-ray diffraction and energy-dispersive x-ray spectroscopy measurements. We postulated that the molybdate rich core is formed due to high segregation coefficient of the Mo ion during the precipitation. The calcination process resulted in crystallization of ?/? (core/shell) NP doped Er and Yb ions, where ?-gadolinium molybdates and ?-molybdates or gadolinium oxide. We confirmed two different upconversion mechanisms. In the presence of molybdenum ions, in the core of the NPs, Yb3+- (?2F7/2, 3T2?) dimers were formed. As a result of a two 980 nm photon absorption by the dimer, we observed enhanced green luminescence in the upconversion process. However, for the shell formed by the Gd2O3:Er, Yb NPs (without the Mo ions), the typical energy transfer upconversion takes place, which results in red luminescence. We demonstrated that the NPs were transported into cytosol of the HeLa and astrocytes cells by endocytosis. The core-shell NPs are sensitive sensors for the environment prevailing inside (shorter luminescence decay) and outside (longer luminescence decay) of the tested cells. The toxicity of the NPs was examined using MTT assay.

Citation I. Kami?ska; D. Elbaum; B. Sikora; P. Kowalik; J. Mikulski; Z. Felcyn; P. Samol; T. Wojciechowski; R. Minikayev; W. Paszkowicz; W. Zaleszczyk; M. Szewczyk; A. Konopka; G. Gruze?; M. Pawlyta; M. Donten; K. Ciszak; K. Zajdel; M. Frontczak-Baniewicz; P. St?pie?; M. ?api?ski; G. Wilczy?ski; K. Fronc.Single-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging.. Nanotechnology. 2018;29(2):025702. doi:10.1088/1361-6528/aa9974

Related Elements

Erbium

See more Erbium products. Erbium (atomic symbol: Er, atomic number: 68) is a Block F, Group 3, Period 6 element with an atomic radius of 167.259. Erbium Bohr ModelThe number of electrons in each of Erbium's shells is [2, 8, 18, 30, 8, 2] and its electron configuration is [Xe]4f12 6s2. The erbium atom has a radius of 176 pm and a Van der Waals radius of 235 pm. Erbium was discovered by Carl Mosander in 1843. Sources of Erbium include the mineral monazite and sand ores. Erbium is a member of the lanthanide or rare earth series of elements.Elemental Erbium Picture In its elemental form, erbium is soft and malleable. It is fairly stable in air and does not oxidize as rapidly as some of the other rare earth metals. Erbium's ions fluoresce in a bright pink color, making them highly useful for imaging and optical applications. It is named after the Swedish town Ytterby where it was first discovered.

Gadolinium

See more Gadolinium products. Gadolinium (atomic symbol: Gd, atomic number: 64) is a Block F, Group 3, Period 6 element with an atomic radius of 157.25. Gadolinium Bohr ModelThe number of electrons in each of Gadolinium's shells is [2, 8, 18, 25, 9, 2] and its electron configuration is [Xe] 4f7 5d1 6s2. The gadolinium atom has a radius of 180 pm and a Van der Waals radius of 237 pm. Gadolinium was discovered by Jean Charles Galissard de Marignac in 1880 and first isolated by Lecoq de Boisbaudran in 1886. In its elemental form, gadolinium has a silvery-white appearance. Gadolinium is a rare earth or lanthanide element that possesses unique properties advantageous to specialized applications such as semiconductor fabrication and nuclear reactor shielding. Elemental Gadolinium PictureIt is utilized for both its high magnetic moment (7.94μ B) and in phosphors and scintillator crystals. When complexed with EDTA ligands, it is used as an injectable contrast agent for MRIs. The element is named after the Finnish chemist and geologist Johan Gadolin.

Ytterbium

See more Ytterbium products. Ytterbium (atomic symbol: Yb, atomic number: 70) is a Block F, Group 3, Period 6 element with an atomic weight of 173.054. Ytterbium Bohr ModelThe number of electrons in each of Ytterbium's shells is [2, 8, 18, 32, 8, 2] and its electron configuration is [Xe]4f14 6s2. The Ytterbium atom has a radius of 176 pm and a Van der Waals radius of 242 pm. Ytterbium was discovered by Jean Charles Galissard de Marignac in 1878 and first isolated by Georges Urbain in 1907.Elemental Ytterbium In its elemental form, ytterbium has a silvery-white color. Ytterbium is found in monazite sand as well as the ores euxenite and xenotime. Ytterbium is named after Ytterby, a village in Sweden. Ytterbium can be used as a source for gamma rays, for the doping of stainless steel, or other active metals. Its electrical resistivity rises under stress, making it very useful for stress gauges that measure the deformation of the ground in the even of an earthquake.

Molybdenum

See more Molybdenum products. Molybdenum (atomic symbol: Mo, atomic number: 42) is a Block D, Group 6, Period 5 element with an atomic weight of 95.96. Molybdenum Bohr ModelThe number of electrons in each of molybdenum's shells is [2, 8, 18, 13, 1] and its electron configuration is [Kr] 4d5 5s1. The molybdenum atom has a radius of 139 pm and a Van der Waals radius of 209 pm. In its elemental form, molybdenum has a gray metallic appearance. Molybdenum was discovered by Carl Wilhelm in 1778 and first isolated by Peter Jacob Hjelm in 1781. Molybdenum is the 54th most abundant element in the earth's crust. Elemental MolybdenumIt has the third highest melting point of any element, exceeded only by tungsten and tantalum. Molybdenum does not occur naturally as a free metal, it is found in various oxidation states in minerals. The primary commercial source of molybdenum is molybdenite, although it is also recovered as a byproduct of copper and tungsten mining. The origin of the name Molybdenum comes from the Greek word molubdos meaning lead.

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