Surface modification of luminescent Ln(III) fluoride core-shell nanoparticles with acetyl salicylic acid (aspirin) - synthesis, spectroscopic and in vitro hemocompatibility studies.

Title Surface modification of luminescent Ln(III) fluoride core-shell nanoparticles with acetyl salicylic acid (aspirin) - synthesis, spectroscopic and in vitro hemocompatibility studies.
Authors D. Kwiatek; L.Mrówczyns Mrówczy?ska; N. Stopikowska; M. Runowski; A. Lesicki; S. Lis
Journal ChemMedChem
DOI 10.1002/cmdc.202000269
Abstract

Luminescent lanthanide fluoride core-shell (LaF3:Tb3+,Ce3+@SiO2-NH2) nanoparticles, with acetyl salicylic acid (aspirin) coated on the surface were obtained. The synthesized products, combining the potential located in the silica shell with the luminescent activity of the core, were characterized in detail with the use of luminescence spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM) methods. The in vitro effects of the modified luminescent nanoparticles on human red blood cell (RBC) membrane permeability, RBC shape, and sedimentation rate, were investigated to assess the hemocompatibility of the obtained compounds. This study demonstrates that the LaF3: Tb3+ 5%, Ce3+ 10%@SiO2-NH2 nanoparticles with acetyl salicylic acid (aspirin) coated on the surface, are very good precursors for multifunctional drug-delivery systems or bio-imaging probe, which can be used safely in potential biomedical applications.

Citation D. Kwiatek; L.Mrówczyns Mrówczy?ska; N. Stopikowska; M. Runowski; A. Lesicki; S. Lis.Surface modification of luminescent Ln(III) fluoride core-shell nanoparticles with acetyl salicylic acid (aspirin) - synthesis, spectroscopic and in vitro hemocompatibility studies.. ChemMedChem. 2020. doi:10.1002/cmdc.202000269

Related Elements

Cerium

See more Cerium products. Cerium (atomic symbol: Ce, atomic number: 58) is a Block F, Group 3, Period 6 element with an atomic weight of 140.116. The number of electrons in each of cerium's shells is 2, 8, 18, 19, 9, 2 and its electron configuration is [Xe]4f2 6s2. Cerium Bohr ModelThe cerium atom has a radius of 182.5 pm and a Van der Waals radius of 235 pm. In its elemental form, cerium has a silvery white appearance. Cerium is the most abundant of the rare earth metals. It is characterized chemically by having two valence states, the +3 cerous and +4 ceric states. The ceric state is the only non-trivalent rare earth ion stable in aqueous solutions. Elemental CeriumIt is therefore strongly acidic and oxidizing, in addition to being moderately toxic.The cerous state closely resembles the other trivalent rare earths. Cerium is found in the minerals allanite, bastnasite, hydroxylbastnasite, monazite, rhabdophane, synchysite and zircon. Cerium was discovered by Martin Heinrich Klaproth, Jöns Jakob Berzelius, and Wilhelm Hisinger in 1803 and first isolated by Carl Gustaf Mosander in 1839. The element was named after the asteroid Ceres, which itself was named after the Roman god of agriculture.

Fluorine

Fluorine is a Block P, Group 17, Period 2 element. Its electron configuration is [He]2s22p5. The fluorine atom has a covalent radius of 64 pm and its Van der Waals radius is 135 pm. In its elemental form, CAS 7782-41-4, fluorine gas has a pale yellow appearance. Fluorine was discovered by André-Marie Ampère in 1810. It was first isolated by Henri Moissan in 1886.

Lanthanum

See more Lanthanum products. Lanthanum (atomic symbol: La, atomic number: 57) is a Block F, Group 3, Period 6 element with an atomic weight of 138.90547. Lanthanum Bohr ModelThe number of electrons in each of lanthanum's shells is [2, 8, 18, 18, 9, 2] and its electron configuration is [Xe] 5d1 6s2. The lanthanum atom has a radius of 187 pm and a Van der Waals radius of 240 pm. Lanthanum was first discovered by Carl Mosander in 1838. In its elemental form, lanthanum has a silvery white appearance.Elemental Lanthanum It is a soft, malleable, and ductile metal that oxidizes easily in air. Lanthanum is the first element in the rare earth or lanthanide series. It is the model for all the other trivalent rare earths and it is the second most abundant of the rare earths after cerium. Lanthanum is found in minerals such as monazite and bastnasite. The name lanthanum originates from the Greek word Lanthaneia, which means 'to lie hidden'.

Terbium

See more Terbium products. Terbium (atomic symbol: Tb, atomic number: 65) is a Block F, Group 3, Period 6 element with an atomic radius of 158.92535.Terbium Bohr Model The number of electrons in each of Terbium's shells is [2, 8, 18, 27, 8, 2] and its electron configuration is [Xe]4f9 6s2. The terbium atom has a radius of 177 pm and a Van der Waals radius of 221 pm.Terbium was discovered and first isolated by Carl Gustaf Mosander in 1842. In its elemental form, terbium is a silvery-white soft metal. Terbium is found in cerite, gadolinite, and monazite. It is not found in nature as a free element. Elemental TerbiumTerbium compounds are brightly fluorescent, and a majority of the world's terbium supply is used for creating green phosphors that enable trichromatic lighting technology. It is also frequently used as a dopant for crystalline solid-state devices and fuel cell materials. It is named after Ytterby, the town in Sweden where it was discovered.

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