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Recent Research & Development for Lutetium
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Biodistributions of (177)Lu- and (111)In-Labeled 7E11 Antibodies to Prostate-Specific Membrane Antigen in Xenograft Model of Prostate Cancer and Potential Use of (111)In-7E11 as a Pre-therapeutic Agent for (177)Lu-7E11 Radioimmunotherapy. Related Articles, LinkOut
Pan MH, Gao DW, Feng J, He J, Seo Y, Tedesco J, Wolodzko JG, Hasegawa BH, Franc BL.
Mol Imaging Biol. 2008 Nov 25; [Epub ahead of print]
PMID: 19034582 [PubMed - as supplied by publisher]
- A comparative study of (131)I and (177)Lu labeled somatostatin analogues for therapy of neuroendocrine tumours. Related Articles, LinkOut
de Araújo EB, Caldeira Filho JS, Nagamati LT, Muramoto E, Colturato MT, Couto RM, Pujatti PB, Mengatti J, Silva CP.
Appl Radiat Isot. 2008 Oct 5; [Epub ahead of print]
PMID: 19027307 [PubMed - as supplied by publisher]
- Studies on the extraction and separation of lanthanide ions with a synergistic extraction system combined with 1,4,10,13-tetrathia-7,16-diazacyclooctadecane and lauric acid. Related Articles, LinkOut
Masuda Y, Zhang Y, Yan C, Li B.
Talanta. 1998 May;46(1):203-13.
PMID: 18967144 [PubMed - in process]
- Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy. Related Articles, LinkOut
Kelly MP, Lee ST, Lee FT, Smyth FE, Davis ID, Brechbiel MW, Scott AM.
Prostate. 2009 Jan 1;69(1):92-104.
PMID: 18942092 [PubMed - in process]
- Efficient sensitization of europium, ytterbium, and neodymium functionalized tris-dipicolinate lanthanide complexes through tunable charge-transfer excited states. Related Articles, LinkOut
D'Aléo A, Picot A, Beeby A, Gareth Williams JA, Le Guennic B, Andraud C, Maury O.
Inorg Chem. 2008 Nov 17;47(22):10258-68. Epub 2008 Oct 21.
PMID: 18937447 [PubMed]
- Micro insert: a prototype full-ring PET device for improving the image resolution of a small-animal PET scanner. Related Articles, LinkOut
Wu H, Pal D, Song TY, O'Sullivan JA, Tai YC.
J Nucl Med. 2008 Oct;49(10):1668-76. Epub 2008 Sep 15.
PMID: 18794253 [PubMed - indexed for MEDLINE]
- The effects of adjuvant experimental radioimmunotherapy and hyperthermic intraperitoneal chemotherapy on intestinal and abdominal healing after cytoreductive surgery for peritoneal carcinomatosis in the rat. Related Articles, LinkOut
Aarts F, Bleichrodt RP, de Man B, Lomme R, Boerman OC, Hendriks T.
Ann Surg Oncol. 2008 Nov;15(11):3299-307. Epub 2008 Aug 19.
PMID: 18712445 [PubMed - in process]
- Simultaneous MR/PET imaging of the human brain: feasibility study. Related Articles, LinkOut
Schlemmer HP, Pichler BJ, Schmand M, Burbar Z, Michel C, Ladebeck R, Jattke K, Townsend D, Nahmias C, Jacob PK, Heiss WD, Claussen CD.
Radiology. 2008 Sep;248(3):1028-35.
PMID: 18710991 [PubMed - indexed for MEDLINE]
- Synthesis and luminescence characterization of cerium doped Lu2O3-Y2O3-La2O3 solid solution transparent ceramics. Related Articles, LinkOut
Yang QH, Zhou HX, Xu J, Su LB.
Opt Express. 2008 Aug 4;16(16):12290-5.
PMID: 18679506 [PubMed - indexed for MEDLINE]
- Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Related Articles, LinkOut
Patel H, Mick R, Finlay J, Zhu TC, Rickter E, Cengel KA, Malkowicz SB, Hahn SM, Busch TM.
Clin Cancer Res. 2008 Aug 1;14(15):4869-76.
PMID: 18676760 [PubMed - indexed for MEDLINE]
- Lutetium oxyorthosilicate (LSO) intrinsic activity correction and minimal detectable target activity study for SPECT imaging with a LSO-based animal PET scanner. Related Articles, LinkOut
Yao R, Ma T, Shao Y.
Phys Med Biol. 2008 Aug 21;53(16):4399-415. Epub 2008 Jul 31.
PMID: 18670052 [PubMed - indexed for MEDLINE]
- Deep-inspiration breath-hold PET/CT of lung cancer: maximum standardized uptake value analysis of 108 patients. Related Articles, LinkOut
Kawano T, Ohtake E, Inoue T.
J Nucl Med. 2008 Aug;49(8):1223-31. Epub 2008 Jul 16.
PMID: 18632812 [PubMed - indexed for MEDLINE]
- O(2) activation and hydrolysis of Salan rare-earth metal alkyl complexes. Related Articles, LinkOut
Liu X, Cui D.
Dalton Trans. 2008 Jul 28;(28):3747-52. Epub 2008 Jun 11.
PMID: 18615222 [PubMed]
- Preparation and preliminary studies on 177Lu-labeled hydroxyapatite particles for possible use in the therapy of liver cancer. Related Articles, LinkOut
Chakraborty S, Das T, Sarma HD, Venkatesh M, Banerjee S.
Nucl Med Biol. 2008 Jul;35(5):589-97.
PMID: 18589303 [PubMed - indexed for MEDLINE]
- A prototype PET scanner with DOI-encoding detectors. Related Articles, LinkOut
Yang Y, Wu Y, Qi J, St James S, Du H, Dokhale PA, Shah KS, Farrell R, Cherry SR.
J Nucl Med. 2008 Jul;49(7):1132-40. Epub 2008 Jun 13.
PMID: 18552140 [PubMed - indexed for MEDLINE]
- Ionic liquid synergistic cation-exchange system for the selective extraction of lanthanum(III) using 2-thenoyltrifluoroacetone and 18-crown-6. Related Articles, LinkOut
Hirayama N, Okamura H, Kidani K, Imura H.
Anal Sci. 2008 Jun;24(6):697-9.
PMID: 18544855 [PubMed]
- Thermal properties of monoclinic KLu(WO4)2 as a promising solid state laser host. Related Articles, LinkOut
Silvestre O, Grau J, Pujol MC, Massons J, Aguiló M, Díaz F, Borowiec MT, Szewczyk A, Gutowska MU, Massot M, Salazar A, Petrov V.
Opt Express. 2008 Mar 31;16(7):5022-34.
PMID: 18542603 [PubMed - indexed for MEDLINE]
- Electric driven molecular switching of asymmetric tris(phthalocyaninato) lutetium triple-decker complex at the liquid/solid interface. Related Articles, LinkOut
Lei SB, Deng K, Yang YL, Zeng QD, Wang C, Jiang JZ.
Nano Lett. 2008 Jul;8(7):1836-43. Epub 2008 Jun 5.
PMID: 18529035 [PubMed]
- Diamagnetic lanthanide tris beta-diketonates as organic-soluble chiral NMR shift reagents. Related Articles, LinkOut
Wenzel TJ, Wenzel BT.
Chirality. 2008 May 27;21(1):6-10 [Epub ahead of print]
PMID: 18506837 [PubMed - as supplied by publisher]
- Transfer of highly hydrophilic ions from water to nitrobenzene, studied by three-phase and thin-film modified electrodes. Related Articles, LinkOut
Charreteur K, Quentel F, Elleouet C, L'Her M.
Anal Chem. 2008 Jul 1;80(13):5065-70. Epub 2008 May 28.
PMID: 18505272 [PubMed]
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Material Safety Data Plate |
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1 Identification of substance
- Product details
- Trade name Lutetium metal
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2 Composition/Data on components:
- Chemical characterization:
Designation: (CAS#)
Lutetium (CAS# 7439-94-3), 100%
- Identification number(s):
- EINECS Number: 231-103-0
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3 Hazards identification
- Hazard designation: · void
- Information pertaining to particular dangers for man and environment
Fine powder:
R 11 Highly flammable
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4 First aid measures
- General information No special measures required.
- After inhalation No special measures required.
- After skin contact The product is not skin irritating.
- After eye contact Seek medical treatment in case of complaints.
- After swallowing Seek medical treatment in case of complaints.
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5 Fire fighting measures
- Suitable extinguishing agents Extinguishing powder. Do not use water.
- For safety reasons unsuitable extinguishing agents Water.
- Protective equipment: No special measures required.
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6 Accidental release measures
- Person-related safety precautions: Not required.
- Measures for environmental protection:
Do not allow material to be released to the environment without proper governmental permits.
- Measures for cleaning/collecting: Collect mechanically.
- Additional information:
See Section 7 for information on safe handling
See section 8 for information on personal protection equipment.
See Section 13 for information on disposal.
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7 Handling and storage
- Handling
- Information for safe handling:
Handle under dry protective gas.
Keep containers tightly sealed.
Store in cool, dry place in tightly closed containers.
No special precautions necessary if used correctly.
- Information about protection against explosions and fires:
Fine powder: highly flammable
- Storage
- Requirements to be met by storerooms and containers:
No special requirements.
- Information about storage in one common storage facility:
Store away from air.
Store away from water.
Do not store together with oxidizing and acidic materials.
Store away from halogens.
- Further information about storage conditions:
Store under dry inert gas.
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8 Exposure controls and personal protection
- Additional information about design of technical systems:
No further data; see item 7.
- Components with critical values that require monitoring at the
workplace:
Not required.
- Additional information: No data
- Personal protective equipment
- General protective and hygienic measures
The usual precautionary measures should be adhered to in handling the chemicals.
- Breathing equipment: Not required.
- Protection of hands: Not required.
- Eye protection: Safety glasses
- Body protection: Protective work clothing.
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9 Physical and chemical properties:
- General Information
- Form: Pieces
- Colour: Silver grey
- Smell: Odourless
- Value/Range Unit Method
- Change in condition
- Melting point/Melting range: 1663 ° C
- Boiling point/Boiling range: 3402 ° C
- Sublimation temperature / start: Not determined
- Flash point: Not applicable
- Inflammability (solid, gaseous) Product is not inflammable.
Powder: flammable
- Ignition temperature: Not determined
- Decomposition temperature: Not determined
- Danger of explosion: Product is not explosive.
- Critical values for explosion:
- Lower: Not determined
- Upper: Not determined
- Steam pressure: Not determined
- Density at 20 ° C 9.84 g/cm³
- Solubility in / Miscibility with
- Water: Not determined
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10 Stability and reactivity
- Thermal decomposition / conditions to be avoided:
No decomposition if used and stored according to specifications.
- Materials to be avoided:
Oxidizing agents
Acids
Halogens
Water/moisture
Air
- Dangerous reactions:
Powder: contact with water liberates extremely flammable gases.
- Dangerous products of decomposition: Metal oxide
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11 Toxicological information
- Acute toxicity:
- Primary irritant effect:
- on the skin: No irritant effect.
- on the eye: No irritant effect.
- Sensitization: No sensitizing effect known.
- Additional toxicological information:
To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.
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12 Ecological information:
- General notes:
Do not allow material to be released to the environment without proper governmental permits.
Water hazard class 1 (Self-assessment): slightly hazardous for water.
Do not allow undiluted product or large quantities of it to reach ground water, water bodies or sewage system.
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13 Disposal considerations
- Product:
- Recommendation
Consult state, local or national regulations for proper disposal.
Hand over to disposers of hazardous waste.
Must be specially treated under adherence to official regulations.
- Uncleaned packagings:
- Recommendation:
Disposal must be made according to official regulations.
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14 Transport information
- Land transport ADR/RID and GGVS/GGVE (cross-border/domestic)
- ADR/RID-GGVS/E Class: None
- Maritime transport IMDG/GGVSea:
- IMDG/GGVSea Class: None
- Air transport ICAO-TI and IATA-DGR:
- ICAO/IATA Class: None
- Transport/Additional information:
Not dangerous according to the above specifications.
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15 Regulatory information
- Designation according to EC guidelines:
Observe the normal safety regulations when handling chemicals
The product is not subject to identification regulations under EC Directives and the Ordinance on Hazardous Materials (GefStoffV).
- National regulations
- Information about limitation of use:
For use only by technically qualified individuals.
- Water hazard class:
Water hazard class 1 (Self-assessment): slightly hazardous for water.
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16 Other information:
Employers should use this information only as a supplement to other information gathered by them, and should make independent judgement of suitability of this information to ensure proper use and protect the health and safety of employees. This information is furnished without warranty, and any use of the product not in conformance with this Material Safety Data Plate, or in combination with any other product or process, is the responsibility of the user.
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Lutetium Foil Recent Research
- Separation of carrier-free hafnium and lutetium radionuclides produced in 16O activated terbium metal target.
Appl Radiat Isot. 2000 Jun;52(6):1399-405.
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