Degradable rhenium trioxide nanocubes with high localized surface plasmon resonance absorbance like gold for photothermal theranostics.

Title Degradable rhenium trioxide nanocubes with high localized surface plasmon resonance absorbance like gold for photothermal theranostics.
Authors W. Zhang; G. Deng; B. Li; X. Zhao; T. Ji; G. Song; Z. Xiao; Q. Cao; J. Xiao; X. Huang; G. Guan; R. Zou; X. Lu; J. Hu
Journal Biomaterials
DOI 10.1016/j.biomaterials.2017.12.021
Abstract

The applications of inorganic theranostic agents in clinical trials are generally limited to their innate non-biodegradability and potential long-term biotoxicity. To address this problem, herein via a straightforward and tailored space-confined on-substrate route, we obtained rhenium trioxide (ReO) nanocubes (NCs) that display a good biocompatibility and biosafety. Importantly, their aqueous dispersion has high localized surface plasmon resonance (LSPR) absorbance in near-infrared (NIR) region different from previous report, which possibly associates with the charge transfer and structural distortion in hydrogen rhenium bronze (HReO), as well as ReO's cubic shape. Such a high LSPR absorbance in the NIR region endows them with photoacoustic (PA)/infrared (IR) thermal imaging, and high photothermal conversion efficiency (?57.0%) for efficient ablation of cancer cells. Also, ReO NCs show X-ray computed tomography (CT) imaging derived from the high-Z element Re. More attractively, those ReO NCs, with pH-dependent oxidized degradation behaviors, are revealed to be relatively stable in hypoxic and weakly acidic microenvironment of tumor for imaging and treatment whilst degradable in normal physiological environments of organs to enable effective clearance. In spite of their degradability, ReO NCs still possess tumor targeting capabilities. We thus develop a simple but powerful, safe and biodegradable inorganic theranostic platform to achieve PA/CT/IR imaging-guided cancer photothermal therapy (PTT) for improved therapeutic efficacy and decreased toxic side effects.

Citation W. Zhang; G. Deng; B. Li; X. Zhao; T. Ji; G. Song; Z. Xiao; Q. Cao; J. Xiao; X. Huang; G. Guan; R. Zou; X. Lu; J. Hu.Degradable rhenium trioxide nanocubes with high localized surface plasmon resonance absorbance like gold for photothermal theranostics.. Biomaterials. 2018;159:6881. doi:10.1016/j.biomaterials.2017.12.021

Related Elements

Rhenium

See more Rhenium products. Rhenium (atomic symbol: Re, atomic number: 75) is a Block D, Group 7, Period 6 element with an atomic weight of 186.207. The number of electrons in each of rhenium's shells is 2, 8, 18, 32, 13, 2 and its electron configuration is [Xe] 4f14 5d5 6s2. Rhenium Bohr ModelThe rhenium atom has a radius of 137 pm and a Van der Waals radius of 217 pm. Rhenium was discovered and first isolated by Masataka Ogawa in 1908. In its elemental form, rhenium has a silvery-white appearance. Rhenium is the fourth densest element exceeded only by platinum, iridium, and osmium. Rhenium's high melting point is exceeded only by those of tungsten and carbon.Elemental Rhenium Rhenium is found in small amounts in gadolinite and molybdenite. It is usually extracted from the flue dusts of molybdenum smelters. The name Rhenium originates from the Latin word 'Rhenus' meaning "Rhine" after the place of discovery.

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