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BIO-MEDICAL GRADE METALS & ALLOYS
INFORMATION CENTER
AE Bio-Medical Grade Materials ™

32.4 (A)/00.022

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Bio-medical grade metals and alloys are used in a variety of applications in the medical field, most commonly; they are used for implant and instrumentation
applications. Research in the orthopedic biomaterials field has increased as the need for such materials has grown due to the aging patient demographics.

Implant alloys are typically derived from three materials systems: stainless steels, cobalt-chromium based alloys and titanium alloys.

Iron Bohr ModelStainless steel was established into general engineering as a new corrosion-resistant material in the early 1900s and was employed in surgical applications soon after. Stainless steel used in medical applications is made out of several components: chromium, nickel and molybdenum. The chromium gives the metal its corrosion and scratch resistance. The nickel offers an even and polished finish. The molybdenum increases hardness and helps sustain a cutting edge.

  Iron Chromium Iron Chromium Nickel Molybdenum
  Iron Chromium Nickel Iron Chromium Nickel Titanium Molybdenum
  Iron Chromium Nickel Copper Iron Chromium Nickel Aluminum
  Iron Chromium Nickel Copper Niobium Iron Chromium Nickel Molybdenum Aluminum
  Iron Chromium Nickel Copper Titanium Niobium Iron Manganese Chromium Molybdenum Nitrogen
  Iron Chromium Nickel Managanese Molybdenum Iron Nickel Copper Molybdenum Niobium
     
Dental Alloys

 

Cobalt Bohr ModelCobalt-chromium based alloys or ceramic materials (aluminum oxide or zirconium oxide) are used in making orthopedic implants. These materials are biocompatible, resistant to corrosion, degradation, and wear, and they have mechanical properties that duplicate the structures they are intended to replace.

  Cobalt Chromium Molybdenum Cobalt Nickel Chromium Iron Molybdenum Titanium
  Cobalt Chromium Nickel Iron Molybdenum Manganese Cobalt Nickel Chromium Iron Molybdenum Tungsten Titanium
  Cobalt Chromium Tungsten Nickel Manganese Cobalt Nickel Chromium Molybdenum

 

Titanium Mesh for Medical Applications

 

Titanium Bohr ModelTitanium has become a fundamental material used in medicine due to its ability to resist corrosion, its biocompatibility and its natural ability to join with human bone. There are many medical materials made with Titanium including, surgical titanium instruments, orthopedic titanium rods, pins and plates, medical and dental titanium. Titanium CP (Commercially Pure) is offered in four types: CP-1 GR 4, CP-2 GR 3, CP-3 GR 2, and CP-4 GR1.

Titanium - Commercially Pure (CP) Titanium based Molybdenum Niobium
Titanium based Aluminum Molybdenum Zirconium Titanium based Molybendum Zirconium Iron
Titanium based Aluminum Niobium Alloy
Titanium Niobium
Titanium based Aluminum Iron Titanium based Niobium Zirconium
Titanium based Aluminum Vanadium Titanium based Niobium Zirconium Tantalum
Titanium based Molybdenum Zirconium Tin
Titanium Mesh
Titanium Molybdenium Alloy Niobium Titanium
  Nitinol NiTi Alloy



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Recent Research & Development for Biomedical Alloys

  • Titanium-Based Biomaterials for Preventing Stress Shielding between Implant Devices and Bone. Niinomi M, Nakai M. Int J Biomater. 2011;2011:836587. Epub 2011 Jun 22. PMID: 21765831 [PubMed - in process]

  • Current progress in inorganic artificial biomaterials. Li Z, Kawashita M. J Artif Organs. 2011 Jul 7. [Epub ahead of print] PMID: 21748443 [PubMed - as supplied by publisher]

  • Preparation and properties of biomedical porous titanium alloys by gelcasting. Yang D, Shao H, Guo Z, Lin T, Fan L. Biomed Mater. 2011 Aug;6(4):045010. Epub 2011 Jul 11. PMID: 21747152 [PubMed - in process]

  • Effect of Manufacturing Process on the Biocompatibility and Mechanical Properties of Ti-30Ta Alloy. Gill P, Munroe N, Pulletikurthi C, Pandya S, Haider W. J Mater Eng Perform. 2011 Jul 1;20(4):819-823. PMID: 21666859 [PubMed]

  • Assessment of Corrosion Resistance and Metal Ion Leaching of Nitinol Alloys. Haider W, Munroe N. J Mater Eng Perform. 2011 Jul 1;20(4):812-815. PMID: 21666858 [PubMed]

  • Stability of Phosphonic Self Assembled Monolayers (SAMs) on Cobalt Chromium (Co-Cr) Alloy under Oxidative conditions. Bhure R, Abdel-Fattah TM, Bonner C, Hall F, Mahapatro A. Appl Surf Sci. 2011 Apr 15;257(13):5605-5612. PMID: 21603056 [PubMed]

  • Development of silver-containing austenite antibacterial stainless steels for biomedical applications part I: microstructure characteristics, mechanical properties and antibacterial mechanisms. Huang CF, Chiang HJ, Lan WC, Chou HH, Ou KL, Yu CH. Biofouling. 2011 May;27(5):449-57. PMID: 21598123 [PubMed - in process]

  • Laser surface modification of titanium substrate for pulsed laser deposition of highly adherent hydroxyapatite. Rajesh P, Muraleedharan CV, Komath M, Varma H. J Mater Sci Mater Med. 2011 Jul;22(7):1671-9. Epub 2011 May 20. PMID: 21598038 [PubMed - in process]

  • Biomedical Ti-Mo Alloys with Surface Machined and Modified by Laser Beam: Biomechanical, Histological, and Histometric Analysis in Rabbits. Oliveira NT, Guastaldi FP, Perrotti V, Hochuli-Vieira E, Guastaldi AC, Piattelli A, Iezzi G. Clin Implant Dent Relat Res. 2011 May 9. doi: 10.1111/j.1708-8208.2011.00354.x. [Epub ahead of print] PMID: 21554530 [PubMed - as supplied by publisher]

  • Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits. Bondarenko A, Hewicker-Trautwein M, Erdmann N, Angrisani N, Reifenrath J, Meyer-Lindenberg A. Biomed Eng Online. 2011 Apr 26;10:32. PMID: 21521497 [PubMed - in process]

  • Antibacterial efficacy of a new gentamicin-coating for cementless prostheses compared to gentamicin-loaded bone cement. Neut D, Dijkstra RJ, Thompson JI, van der Mei HC, Busscher HJ. J Orthop Res. 2011 Apr 13. doi: 10.1002/jor.21433. [Epub ahead of print] PMID: 21491478 [PubMed - as supplied by publisher]

  • Surface modifications of magnesium alloys for biomedical applications. Yang J, Cui F, Lee IS. Ann Biomed Eng. 2011 Jul;39(7):1857-71. Epub 2011 Mar 29. PMID: 21445692 [PubMed - in process]

  • Corrosion resistance evaluation of Pd-free Ag-Au-Pt-Cu dental alloys. Fujita T, Shiraishi T, Takuma Y, Hisatsune K. Dent Mater J. 2011;30(2):136-42. Epub 2011 Mar 10. PMID: 21415553 [PubMed - in process]

  • Transient elastohydrodynamic lubrication analysis of a novel metal-on-metal hip prosthesis with a non-spherical femoral bearing surface. Meng QE, Liu F, Fisher J, Jin ZM. Proc Inst Mech Eng H. 2011 Jan;225(1):25-37. PMID: 21381485 [PubMed - indexed for MEDLINE]

  • Preparation of bioactive Ti-15Zr-4Nb-4Ta alloy from HCl and heat treatments after an NaOH treatment. Yamaguchi S, Takadama H, Matsushita T, Nakamura T, Kokubo T. J Biomed Mater Res A. 2011 May;97(2):135-44. doi: 10.1002/jbm.a.33036. Epub 2011 Mar 2. PMID: 21370443 [PubMed - indexed for MEDLINE]

  • Enhancing the soft tissue seal around intraosseous transcutaneous amputation prostheses using silanized fibronectin titanium alloy. Chimutengwende-Gordon M, Pendegrass C, Blunn G. Biomed Mater. 2011 Apr;6(2):025008. Epub 2011 Feb 28. PMID: 21358026 [PubMed - indexed for MEDLINE]

  • Can human mesenchymal stem cells survive on a NiTi implant material subjected to cyclic loading? Habijan T, Glogowski T, Kühn S, Pohl M, Wittsiepe J, Greulich C, Eggeler G, Schildhauer TA, Köller M. Acta Biomater. 2011 Jun;7(6):2733-9. Epub 2011 Feb 21. PMID: 21345390 [PubMed - in process]

  • Strength enhancement of a biomedical titanium alloy through a modified accumulative roll bonding technique. Kent D, Wang G, Yu Z, Ma X, Dargusch M. J Mech Behav Biomed Mater. 2011 Apr;4(3):405-16. Epub 2010 Dec 3. PMID: 21316628 [PubMed - indexed for MEDLINE]

  • The bone tissue compatibility of a new Ti-Nb-Sn alloy with a low Young's modulus. Miura K, Yamada N, Hanada S, Jung TK, Itoi E. Acta Biomater. 2011 May;7(5):2320-6. Epub 2011 Feb 26. PMID: 21316491 [PubMed - indexed for MEDLINE]

  • Hemocompatibility of silicon-based substrates for biomedical implant applications. Muthusubramaniam L, Lowe R, Fissell WH, Li L, Marchant RE, Desai TA, Roy S. Ann Biomed Eng. 2011 Apr;39(4):1296-305. Epub 2011 Feb 2. PMID: 21287275 [PubMed - indexed for MEDLINE]


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