A facile way to fabricate manganese phosphate self-assembled carbon networks as efficient electrochemical catalysts for real-time monitoring of superoxide anions released from HepG2 cells.

Title A facile way to fabricate manganese phosphate self-assembled carbon networks as efficient electrochemical catalysts for real-time monitoring of superoxide anions released from HepG2 cells.
Authors X. Cai; L. Shi; W. Sun; H. Zhao; H. Li; H. He; M. Lan
Journal Biosens Bioelectron
DOI 10.1016/j.bios.2017.11.020
Abstract

Quantification of superoxide anions (O) is significant in the monitoring of many serious diseases and the design of enzyme-mimic catalysts plays the main role in the development of non-enzymatic Osensors. Herein, we proposed a facile self-assembly process to synthesize manganese phosphate modified carbon networks using three kinds of widely-used carbon materials (MWCNTs, NGS and GO) as pillar connectors. Characterizations demonstrate that manganese phosphate is widely dispersed inside and on the surface of carbon networks without visible morphology. Meanwhile, all three kinds of synthesized catalysts were successfully immobilized on the screen-printed carbon electrodes to evaluate the electrochemical performance of fabricated sensors. The results indicate that sensors based on Mn(PO)modified MWCNTs exhibit high sensitivity with an extremely low detection limit of 0.127?M (S/N = 3) and a wide liner range of 0-1.817mM (R= 0.998). We further employed the recommended sensors in the real-time monitoring of HepG2 cells released Ounder the stimulating of Zymosan (20mg/mL). Noticeably, the proposed sensors exhibit not only sensitive response but also stable current steps upon different addition of Zymosan. The calculated concentrations of cell-released Ovary from 6.772 to 24.652pM cellfor the Zymosan amount used in this work. The established novel sensors display low background current and signal noises, thus holding unique advantages in the trace analysis of Oin biological samples and in vivo environment.

Citation X. Cai; L. Shi; W. Sun; H. Zhao; H. Li; H. He; M. Lan.A facile way to fabricate manganese phosphate self-assembled carbon networks as efficient electrochemical catalysts for real-time monitoring of superoxide anions released from HepG2 cells.. Biosens Bioelectron. 2018;102:171178. doi:10.1016/j.bios.2017.11.020

Related Elements

Manganese

See more Manganese products. Manganese (atomic symbol: Mn, atomic number: 25) is a Block D, Group 7, Period 4 element with an atomic weight of 54.938045. Manganese Bohr ModelThe number of electrons in each of Manganese's shells is [2, 8, 13, 2] and its electron configuration is [Ar] 3d5 4s2. The manganese atom has a radius of 127 pm and a Van der Waals radius of 197 pm. Manganese was first discovered by Torbern Olof Bergman in 1770 and first isolated by Johann Gottlieb Gahn in 1774. In its elemental form, manganese has a silvery metallic appearance. Elemental ManganeseIt is a paramagnetic metal that oxidizes easily in addition to being very hard and brittle. Manganese is found as a free element in nature and also in the minerals pyrolusite, braunite, psilomelane, and rhodochrosite. The name Manganese originates from the Latin word mangnes, meaning "magnet."

Phosphorus

Phosphorus Bohr ModelSee more Phosphorus products. Phosphorus (atomic symbol: P, atomic number: 15) is a Block P, Group 15, Period 3 element. The number of electrons in each of Phosphorus's shells is 2, 8, 5 and its electronic configuration is [Ne] 3s2 3p3. The phosphorus atom has a radius of 110.5.pm and its Van der Waals radius is 180.pm. Phosphorus is a highly-reactive non-metallic element (sometimes considered a metalloid) with two primary allotropes, white phosphorus and red phosphorus its black flaky appearance is similar to graphitic carbon. Compound forms of phosphorus include phosphates and phosphides. Phosphorous was first recognized as an element by Hennig Brand in 1669 its name (phosphorus mirabilis, or "bearer of light") was inspired from the brilliant glow emitted by its distillation.

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