Biodistribution and PET Imaging of 89-Zirconium Labelled Cerium Oxide Nanoparticles Synthesized with Several Surface Coatings.

Title Biodistribution and PET Imaging of 89-Zirconium Labelled Cerium Oxide Nanoparticles Synthesized with Several Surface Coatings.
Authors P.Reed McDonagh; G. Sundaresan; L. Yang; M. Sun; R. Mikkelsen; J. Zweit
Journal Nanomedicine
DOI 10.1016/j.nano.2018.04.002
Abstract

Cerium oxide nanoparticles (CONPs) have unique surface chemistry allowing catalyst-like antioxidant properties, and are being investigated for several disease indications in medicine. Studies have utilized surface modified CONPs toward this application, but have been lacking in comprehensive biodistribution and pharmacokinetic data and a direct comparison to uncoated CONPs. We developed an enhanced single-pot synthesis of several coated CONPs and an efficient intrinsic core labeling of CONPs with the clinical PET isotope, zirconium-89, allowing detailed PET imaging and ex vivo biodistribution. All coated [Zr]-CONPs showed benefit in terms of biodistribution compared to uncoated [Zr]-CONPs, while retaining the intrinsic antioxidant properties. Among these, poly(acrylic acid) coated CONPs demonstrated excellent candidacy for clinical implementation due to their enhanced renal clearance and low reticuloendothelial system uptake. This work also demonstrates the value of intrinsic core labeling and PET imaging for evaluation of nanoparticle constructs to better inform future studies towards clinical use.

Citation P.Reed McDonagh; G. Sundaresan; L. Yang; M. Sun; R. Mikkelsen; J. Zweit.Biodistribution and PET Imaging of 89-Zirconium Labelled Cerium Oxide Nanoparticles Synthesized with Several Surface Coatings.. Nanomedicine. 2018. doi:10.1016/j.nano.2018.04.002

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Zirconium

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Cerium

See more Cerium products. Cerium (atomic symbol: Ce, atomic number: 58) is a Block F, Group 3, Period 6 element with an atomic weight of 140.116. The number of electrons in each of cerium's shells is 2, 8, 18, 19, 9, 2 and its electron configuration is [Xe]4f2 6s2. Cerium Bohr ModelThe cerium atom has a radius of 182.5 pm and a Van der Waals radius of 235 pm. In its elemental form, cerium has a silvery white appearance. Cerium is the most abundant of the rare earth metals. It is characterized chemically by having two valence states, the +3 cerous and +4 ceric states. The ceric state is the only non-trivalent rare earth ion stable in aqueous solutions. Elemental CeriumIt is therefore strongly acidic and oxidizing, in addition to being moderately toxic.The cerous state closely resembles the other trivalent rare earths. Cerium is found in the minerals allanite, bastnasite, hydroxylbastnasite, monazite, rhabdophane, synchysite and zircon. Cerium was discovered by Martin Heinrich Klaproth, Jöns Jakob Berzelius, and Wilhelm Hisinger in 1803 and first isolated by Carl Gustaf Mosander in 1839. The element was named after the asteroid Ceres, which itself was named after the Roman god of agriculture.

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