Albumin-Encapsulated Platinum Nanoparticles for Targeted Photothermal Treatment of Glioma.

Author(s) Chang, C.; Wang, C.; Zhang, C.; Li, L.; Zhang, Q.; Huang, Q.
Journal J Biomed Nanotechnol
Date Published 2019 Aug 01
Abstract

Brain tumors are hard to cure due to the life-threatening impact on the vital function areas of brain plus the blood-brain barrier caused poor drug delivery to brain. In this study, we utilized the human serum albumin (HSA) as a template to synthesize ultrasmall platinum nanoparticle for targeted photothermal treatment of glioma. The HSA-encapsulated platinum nanoparticle (HSA-Pt) possessed uniform size and shape, and represented excellent photothermal effect. As an endogenous protein in blood, HSA endowed HSA-Pt great biocompatibility and prolonged blood circulation time. In a subcutaneous model, HSA-Pt accumulated more in tumors than the control nanoparticle due to its long circulation time, resulting in more efficient photothermal regression of tumors. Furthermore, in an orthotropic glioma model, HSA-Pt was able to penetrate the blood-brain barrier and target to glioma, and the tumors were significantly suppressed by photothermal therapy. This study suggests HSA-Pt associated targeted photothermal therapy can be used for the treatment of brain tumors.

DOI 10.1166/jbn.2019.2803
Keywords Albumins; Cell Line, Tumor; Glioma; Humans; Metal Nanoparticles; Platinum
ISSN 1550-7033
Citation Chang C, Wang C, Zhang C, Li L, Zhang Q, Huang Q. Albumin-Encapsulated Platinum Nanoparticles for Targeted Photothermal Treatment of Glioma. J Biomed Nanotechnol. 2019;15(8):1744-1753.

Related Applications, Forms & Industries