Antimicrobial Peptide-Templated Silver Nanoclusters with Membrane Activity for Enhanced Bacterial Killing.

Author(s) Fei, X.; Ma, X.; Fang, G.; Chong, Y.; Tian, X.; Ge, C.
Journal J Nanosci Nanotechnol
Date Published 2020 Mar 01

We aimed to develop antimicrobial agents that satisfy biosafety considerations while exhibiting efficient antimicrobial activity. Peptide-capped silver nanoclusters (peptide@AgNCs) were designed. In addition, the antimicrobial activity and mechanism of peptide@AgNCs were studied. The hemolysis and cytotoxicity tests on mammalian cells were used to confirm the biocompatibility of peptide@ AgNCs. KLA@AgNCs exhibited dramatic antimicrobial activity without inducing significant cytotoxicity in mammalian cells. The KLA@AgNCs destroyed the integrity of the bacterial membrane and induced ROS accumulation, causing oxidative damage to biomolecules. The malfunction of the respiratory chain complexes I and V completely suppresses the energy production, ultimately accelerating the death of the bacteria. Our findings may advance the development of Ag-based nanomaterials with enhanced bactericidal activity and improved biocompatibility.

DOI 10.1166/jnn.2020.17161
ISSN 1533-4899
Citation J Nanosci Nanotechnol. 2020;20(3):14251433.

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