Antioxidant Sulfated Polysaccharide from Edible Red Seaweed is an Inhibitor of Calcium Oxalate Crystal Formation.

Author(s) Oliveira, L.Castelo Br; Queiroz, M.Fernandes; Fidelis, G.Pereira; Melo, K.Rachel Teo; Câmara, R.Barros Gom; Alves, M.Gabriela C.; Costa, L.Silva; Teixeira, D.Inácio Al; Melo-Silveira, R.Fagundes; Rocha, H.Alexandre
Journal Molecules
Date Published 2020 Apr 28

The genus synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed , have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from . In this study, a galactan (GB) was extracted from and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world's population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent.

DOI 10.3390/molecules25092055
ISSN 1420-3049
Citation Molecules. 2020;25(9).

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