Bismuth Triflate-Catalyzed Vinylogous Nucleophilic 1,6-Conjugate Addition of para-Quinone Methides with 3-Propenyl-2-silyloxyindoles.

Author(s) Xie, K.X.; Zhang, Z.P.; Li, X.
Journal Org Lett
Date Published 2017 Dec 15

A highly diastereoselective vinylogous nucleophilic 1,6-conjugate addition reaction of para-quinone methides with 3-propenyl-2-silyloxyindoles by a bismuth triflate catalyst has been developed. A number of diphenylmethane type compounds functionalized with oxindole motifs was obtained with excellent yields (up to 99%) and very good diastereoselectivities (up to Z/E > 99:1).

DOI 10.1021/acs.orglett.7b03433
ISSN 1523-7052
Citation Org Lett. 2017;19(24):67086711.

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