Evaluation of the lubricating effect of magnesium stearate and glyceryl behenate solid lipid nanoparticles in a direct compression process.

Author(s) Martínez-Acevedo, L.; Zambrano-Zaragoza, Mde la Luz; Vidal-Romero, G.; Mendoza-Elvira, S.; Quintanar-Guerrero, D.
Journal Int J Pharm
Date Published 2018 Jul 10
Abstract

The aim of this study was to develop solid lipid nanoparticles (SLN) and introduce them into a direct compression process to evaluate their lubricant properties. The study consisted of preparing glyceryl behenate SLN (Compritol® 888 ATO) by hot dispersion, and magnesium stearate SLN by a novel nanoprecipitation/ion exchange method. The ejection force was measured for nanosystems and raw materials in a formulation typically used for direct compression. The smallest particle sizes obtained were 456 nm for Compritol® 888 ATO and 330 nm for magnesium stearate. Results show that the NPs used as lubricants in a direct compression model formulation provided efficient lubrication by maintaining the lubricating properties of the system, thereby decreasing the amount of lubricant used compared to the raw material. The lubricating effect showed an increase of 15-30% for magnesium stearate and Compritol® 888 ATO, compared to the raw material at concentrations above 2%.

DOI 10.1016/j.ijpharm.2018.05.002
ISSN 1873-3476
Citation Martínez-Acevedo L, Zambrano-Zaragoza Md, Vidal-Romero G, Mendoza-Elvira S, Quintanar-Guerrero D. Evaluation of the lubricating effect of magnesium stearate and glyceryl behenate solid lipid nanoparticles in a direct compression process. Int J Pharm. 2018;545(1-2):170-175.

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