Facile synthesis of Silicon quantum dot-Gadolinium: A potential fluorescent/T1-T2 multimodal imaging agent.

Author(s) Xiao, F.; Xiao, Y.; Chen, F.; Liu, X.; Lin, C.; Chen, J.; Wu, Y.
Journal Talanta
Date Published 2019 Jul 01
Abstract

Highly stable and multifunctional fluorescent quantum dots are particularly attractive in practical applications. Here, a new kind of ultra-small-sized silicon quantum dot-gadolinium (SiQD-Gd) was successfully fabricated by a newly-designed facile hydrothermal growth and chelating method. The obtained SiQD-Gd exhibited outstanding water dispersibility, stability and good fluorescent property with the quantum yield of 11.6%. SiQD-Gd displayed a low cytotoxicity in normal cell lines (HELF, HEK293F) and tumor cell lines (H1299, A549). Meanwhile, SiQD-Gd showed excellent magnetic resonance response with r relaxation rate of 10.5 mmol L·s and r relaxation rate of 47.5 mmol L·s, which are 2.5 and 7.4 times enhanced comparing to that of the commercial MR agent Magnevist. In vivo studies showed significant contrast enhancement effect of its T- and T-weighted MR imaging. In addition, in vivo fluorescent imaging for mice and zebrafish indicated its potential applications in fluorescent tracking. Thus, the excellent multimodal imaging capacity and biocompatibility of SiQD-Gd make it a potential imaging agent for clinic applications.

DOI 10.1016/j.talanta.2019.02.041
ISSN 1873-3573
Citation Xiao F, Xiao Y, Chen F, Liu X, Lin C, Chen J, et al. Facile synthesis of Silicon quantum dot-Gadolinium: A potential fluorescent/T1-T2 multimodal imaging agent. Talanta. 2019;199:336-346.

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