Glycyrrhizin protects against sodium iodate-induced RPE and retinal injury though activation of AKT and Nrf2/HO-1 pathway.

Author(s) He, H.; Wei, D.; Liu, H.; Zhu, C.; Lu, Y.; Ke, Z.; Jiang, S.; Huang, J.
Journal J Cell Mol Med
Date Published 2019 05
Abstract

Glycyrrhizin is a bioactive triterpenoid saponin extracted from a traditional Chinese medicinal herb, glycyrrhiza, and has been reported to protect the organs such as liver and heart from injuries. However, there is no report about the effects of glycyrrhizin on atrophic age-related macular degeneration (AMD). This study investigated the effects of glycyrrhizin on retinal pigment epithelium (RPE) in vitro and retina of mice in vivo treated with sodium iodate (SI). Glycyrrhizin significantly inhibited SI-induced reactive oxygen species (ROS), and decreased apoptosis of RPE in vitro. The underlying mechanisms included increased phosphorylation of Akt, and increased expression of nuclear factor erythroid 2-related factor2 (Nrf-2) and HO-1, thereby protecting RPE from SI-induced ROS and apoptosis. Furthermore, glycyrrhizin significantly decreased the apoptosis of retinal cells in vivo, resulting in the inhibition of thinning of retina, decreasing the number of drusen and improving the function of retina. These findings suggested that glycyrrhizin may be a potential candidate for the treatment of atrophic AMD in clinical practice.

DOI 10.1111/jcmm.14246
Keywords Animals; Apoptosis; Cell Line; Glycyrrhizic Acid; Heme Oxygenase-1; Humans; Iodates; Male; Mice, Inbred C57BL; NF-E2-Related Factor 2; Protective Agents; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Retina; Retinal Diseases; Retinal Pigment Epithelium; Signal Transduction
ISSN 1582-4934
Citation He H, Wei D, Liu H, Zhu C, Lu Y, Ke Z, et al. Glycyrrhizin protects against sodium iodate-induced RPE and retinal injury though activation of AKT and Nrf2/HO-1 pathway. J Cell Mol Med. 2019;23(5):3495-3504.

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