In vitro efficacy of a novel potassium oxalate hydrogel for dentin hypersensitivity.

Author(s) Varoni, E.M.; Zuccheri, T.; Carletta, A.; Palazzo, B.; Cochis, A.; Colonna, M.; Rimondini, L.
Journal Eur J Oral Sci
Date Published 2017 Apr

A novel potassium oxalate-based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance as a remineralizing, desensitizing agent. Etched disks of human dentin were treated for 10 or 20 min using the test hydrogel, to mimic a professional application with dental mouth guards. Dentin disks were evaluated in terms of permeability indexes in a fluid-filled system, the surface morphology was assessed by scanning electron microscopy, and the structural properties were studied using X-ray diffraction analysis. The potassium oxalate hydrogel significantly reduced dentin permeability, in a time-dependent manner, and occluded most of the patent dentinal tubules via crystal precipitation, forming a remineralized layer. After hydrogel treatments, an acid solution (pH 4.2) was applied to the disks for 30 s, or 1, 2, or 5 min, in order to reproduce a plaque-like oral acidity, and further analysis showed a good resistance of the remineralized layer to the acid challenge. The potassium oxalate-based hydrogel showed a better performance over commercially available products and artificial saliva, appearing a promising candidate for the treatment of dentin hypersensitivity.

DOI 10.1111/eos.12334
ISSN 1600-0722
Citation Eur J Oral Sci. 2017;125(2):151159.

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