In vivo antibacterial property of Ti-Cu sintered alloy implant.

Author(s) Wang, X.; Dong, H.; Liu, J.; Qin, G.; Chen, D.; Zhang, E.
Journal Mater Sci Eng C Mater Biol Appl
Date Published 2019 Jul
Abstract

In-vivo antibacterial property of Ti10Cu sintered alloy was investigated in comparison with pure titanium (cp-Ti) by implanting the alloys with S. aureus suspension in the muscles of rabbits. The general appearance, the white blood cell (WBC) number, the bacteria number were checked and the pathological examination were analyzed. It has been shown that serious inflammation at day 4 and fester at day 14 were observed after implantation in cp-Ti group while only mild infection was observed at day 4 in the case of Ti10Cu implants. Bacterial incubation results have also shown that lots of S. aureus were found in cp-Ti group at all intervals while only several bacteria at day 1 and day 4 and no bacteria after 7 days postimplantation can be found in Ti10Cu group. All these results demonstrate the strong in vivo antibacterial property of Ti10Cu alloy. The strong antibacterial property suggests that Ti10Cu alloy might have potential application in orthopedic surgery and dental implant to reduce the implant-related infection or inflammation.

DOI 10.1016/j.msec.2019.02.084
ISSN 1873-0191
Citation Wang X, Dong H, Liu J, Qin G, Chen D, Zhang E. In vivo antibacterial property of Ti-Cu sintered alloy implant. Mater Sci Eng C Mater Biol Appl. 2019;100:38-47.

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