Author(s) Park, J.; Kim, T.; Kim, H.Jun; Hong, J.I.
Journal Dalton Trans
Date Published 2019 Apr 02

Since abnormal levels of hydrogen sulphide (H2S) correlate with various diseases, simple methods for its rapid and sensitive detection are highly required. Herein, we introduce a new electrochemiluminescent probe 1 for H2S based on a cyclometalated iridium(iii) complex. o-(Azidomethyl)benzoate ester groups on the main ligands of probe 1 react selectively with H2S, resulting in cascade reactions involving H2S-mediated reduction and intramolecular cyclization/ester cleavage. With this structural change induced by H2S, the intrinsic electrochemiluminescence (ECL) of 1 decreased greatly due to the unfavourable electron transfer of a tripropylamine (TPA) radical. Probe 1 showed a high ECL turn-off ratio and good selectivity for H2S over various anions and biothiols. The sensing mechanism of H2S was elucidated using 1H NMR spectroscopy and MALDI-TOF mass spectrometry analyses.

DOI 10.1039/c8dt04901g
ISSN 1477-9234
Citation Park J, Kim T, Kim HJ, Hong J-. Iridium(III) complex-based electrochemiluminescent probe for HS. Dalton Trans. 2019;48(14):4565-4573.

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