Author(s) Jain, A.; Koyani, R.; Muñoz, C.; Sengar, P.; Contreras, O.E.; Juárez, P.; Hirata, G.A.
Journal J Colloid Interface Sci
Date Published 2018 Sep 15
Abstract

Nanoparticle (NP) and photosensitizer (PS) conjugates capable of X-ray photodynamic therapy (X-PDT) are a research focus due to their potential applications in cancer treatment. Combined with X-PDT, appropriate imaging properties of the nanocomposite will make it suitable for theranostics of deep lying tumors. In this work, we describe the development of magnetic-luminescent GdCeAlO nanoparticles (GAG) coated with mesoporous silica (mSiO) and loaded with rose bengal (RB) to yield a nanocomposite GAG@mSiO@RB capable of X-PDT. GAG nanoparticles were synthesized using the sol-gel method. The synthesized GAG nanoparticles showed a strong visible yellow emission with a quantum yield of ∼32%. Moreover, the broad emission spectra of GAG nanoparticles centered at 585 nm showed a good overlap with the absorption of RB. Upon irradiation with X-rays (55 KV), the GAG@mSiO@RB nanocomposite produced significantly higher singlet oxygen compared with RB alone, as confirmed by the 1,2-diphenylisobenzofuran (DPBF) assay. The developed GAG@mSiO@RB nanocomposite significantly reduced the viability of human breast cancer (MDA-MB-231) cells upon irradiation with blue light (λ = 470 nm). The calculated LC of GAG@mSiO@RB nanocomposites were 26.69, 11.2, and 6.56 µg/mL at a dose of ∼0.16, 0.33 and 0.5 J/cm, respectively. Moreover, the nanocomposite showed paramagnetic properties with high magnetic mass susceptibility which are useful for high contrast T weighted magnetic resonance imaging (MRI). Together with X-PDT, the paramagnetic properties of the proposed GAG@mSiO@RB nanocomposite system are promising for their future application in simultaneous detection and treatment of deep-lying tumors.

DOI 10.1016/j.jcis.2018.04.100
ISSN 1095-7103
Citation J Colloid Interface Sci. 2018;526:220229.

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