Neurodegenerative and Hepatorenal Disorders Induced Via Aluminum Chloride in Murine System: Impact of β-Secretase, MAPK, and KIM.

Author(s) Hassan, S.Aly; Kadry, M.O.
Journal Biol Trace Elem Res
Date Published 2020 Apr 11

Aluminum chloride (AlCl) is commonly used in daily life; meanwhile, it is the potential etiology of various neurodegenerative as well as hepatorenal diseases. Therefore, the present study was carried out to investigate the correlation between AlCl-induced biochemical alterations and the toxicity induced in various organs such as the brain, liver, and kidney. Male mice received AlCl in an oral dose of 50 mg kg in addition to (50 mg) in drinking water for 2 weeks. Two weeks post-AlCl intoxication, the brain, liver, and kidney biochemical indices were assessed via molecular and western blot analysis. The results are as follows: AlCl intoxication induced a significant elevation in serum malondialdehyde in addition to a significant reduction in serum glutathione (GSH) and superoxide dismutase (SOD) levels. Brain β-secretase (tubulin-binding protein) and tau proteins which are responsible for the synthesis of β-amyloid protein that may interfere with neuronal communication in Alzheimer's disease (AD) were also upregulated; regarding hepatic function, AlCl elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Moreover, it upregulated hepatic mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) protein expressions as well as renal kidney-inducible molecule-1 (KIM-1) which indicated the deleterious effect of AlCl on these organs. These results were confirmed by histopathological investigations. So, we hypothesize that acute AlCl administration is responsible for oxidative cell damage that interferes with brain function inducing β-amyloid accumulation, Alzheimer's disease, and neurodegenerative damage as well as hepatorenal injuries.

DOI 10.1007/s12011-020-02132-9
ISSN 1559-0720
Citation Biol Trace Elem Res. 2020.

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