Nucleophilic Amination of Methoxy Arenes by a Sodium Hydride-Iodide Composite.

Author(s) Kaga, A.; Hayashi, H.; Hakamata, H.; Oi, M.; Uchiyama, M.; Takita, R.; Chiba, S.
Journal Angew Chem Int Ed Engl
Date Published 2017 Jul 25

A new protocol for nucleophilic amination of methoxy arenes was established using sodium hydride (NaH) in the presence of lithium iodide (LiI), offering an efficient route to supply benzannulated nitrogen-heterocycles. Mechanistic studies showed that unusual concerted nucleophilic aromatic substitution operates in the present process.

DOI 10.1002/anie.201705916
ISSN 1521-3773
Citation Angew Chem Int Ed Engl. 2017.

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