Optically active neodymium hydroxide surface-functionalized mesoporous silica micro-cocoons for biomedical applications.

Author(s) Ansari, A.A.; Khan, A.; Alam, M.; Siddiqui, M.A.; Ahmad, N.; Alkhedhairy, A.A.
Journal Colloids Surf B Biointerfaces
Date Published 2020 May

Neodymium hydroxide (Nd(OH))-surface modified mesoporous silica micro-cocoon microstructures were prepared using a facile single-step sol-gel chemical process. XRD revealed the semi-crystalline nature of the as-prepared materials. TEM and SEM micrographs exhibited highly monodisperse, non-aggregated, typical ordered mesoporous, and irregular sized cocoon-shaped micro-structures with a narrow size distribution. Optical properties, that were examined in the aqueous media, revealed a high colloidal stability and the formation of a semi-transparent colloidal solution. The colloidal solution of Nd(OH)-surface functionalized micro-structures revealed well characteristics absorption bands of Nd ions in the visible region. thus validating the successful coating of SiO@Nd(OH) layer over the surface silica forming core-shell structures. Zeta potential, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) bromide, and neutral red uptake assays were applied in a dose-dependent manner to investigate the biocompatibility and toxic potential of the designed cocoon-shaped microstructures. Both the assays and the high zeta potential value demonstrated good cell viability even at high concentrations and hydrophilic conditions, indicating excellent biocompatibility and non-toxicity. These highly hydrophilic, optically active, mesoporous, biocompatible, and non-toxic cocoon-shaped microstructures could be potentially suitable candidates for optical bio-probes and drug delivery applications.

DOI 10.1016/j.colsurfb.2020.110877
ISSN 1873-4367
Citation Colloids Surf B Biointerfaces. 2020;189:110877.

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