Organocatalytic Cascade β-Functionalization/Aromatization of Pyrrolidines via Double Hydride Transfer.

Author(s) Zhou, L.; De An, X.; Yang, S.; Li, X.J.; Shao, C.L.; Liu, Q.; Xiao, J.
Journal Org Lett
Date Published 2020 Feb 07

An unprecedented cascade β-functionalization/aromatization reaction of -arylpyrrolidines was established. A series of β-substituted arylpyrroles embedded with trifluoromethyl groups are provided directly from -arylpyrrolidines. The deuterium-labeling experiments indicate that sequential double hydride transfer processes serve as the key steps in this transformation.

DOI 10.1021/acs.orglett.9b03918
ISSN 1523-7052
Citation Org Lett. 2020;22(3):776780.

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