Author(s) Gvozdev, D.A.; Lukashev, E.P.; Gorokhov, V.V.; Pashchenko, V.Z.
Journal Biochemistry (Mosc)
Date Published 2019 Aug

Interaction between upconverting nanoparticles and aluminum octacarboxyphthalocyanine was studied. The efficiency of non-radiative energy transfer from the nanoparticles to phthalocyanine increased with the number of phthalocyanine molecules adsorbed on the nanoparticle, but only up to a certain limit. Further increase in the phthalocyanine concentration resulted in a decrease of its sensitized fluorescence due to the dimerization of dye molecules on the nanoparticle surface. When subjected to infrared irradiation, phthalocyanine molecules in the hybrid complex generated singlet oxygen. The observed effects are of interest in regard to the targeted search for new components of efficient third-generation hybrid photosensitizers.

DOI 10.1134/S0006297919080078
Keywords Drug Discovery; Fluorescence; Fluorescence Resonance Energy Transfer; Indoles; Infrared Rays; Microscopy, Electron, Transmission; Nanoparticles; Neoplasms; Organometallic Compounds; Osmolar Concentration; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen
ISSN 1608-3040
Citation Biochemistry Mosc. 2019;84(8):911922.