Physics of Spontaneous Calcium Oscillations in Cardiac Cells and Their Entrainment.

Author(s) Cohen, O.; Safran, S.A.
Journal Phys Rev Lett
Date Published 2019 May 17
Abstract

Mechanical contraction in muscle cells requires Ca to allow myosin binding to actin. Beating cardiomyocytes contain internal Ca stores whose cytoplasmic concentration oscillates. Our theory explains observed single channel dynamics as well as cellular oscillations in spontaneously beating cardiomyocytes. The Ca dependence of channel activity responsible for Ca release includes positive feedback with a delayed response. We use this to predict a dynamical equation for global calcium oscillations with only a few physically relevant parameters. The theory accounts for the observed entrainment of beating to an oscillatory electric or mechanical field.

DOI 10.1103/PhysRevLett.122.198101
ISSN 1079-7114
Citation Cohen O, Safran SA. Physics of Spontaneous Calcium Oscillations in Cardiac Cells and Their Entrainment. Phys Rev Lett. 2019;122(19):198101.