Preparation, characterization and evaluation of the zinc titanate and silver nitrate incorporated wipes for topical chemical and biological decontamination.

Author(s) Sharma, N.; Chaudhary, M.; Butola, B.Singh; Jeyabalaji, J.Kingston; Pathak, D.Pal; Sharma, R.Kumar
Journal Mater Sci Eng C Mater Biol Appl
Date Published 2019 Mar
Abstract

Chemical and biological warfare agents have detrimental effects on biological systems. These agents are rapidly absorbed through skin and hence warrant immediate decontamination. Zinc titanate (ZnTiO), is a well-proven moiety used for neutralizing chemical warfare agents (CWA) and silver is widely used as an antibacterial agent. Spacer fabric sheet, due to its ability to hold large amount of agents, was hydrothermally treated with silver nitrate (AgNO) and incorporated with nano ZnTiO to prepare decontamination (deconwipes). Prepared deconwipe was characterized using X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). Uniform deposition of nano ZnTiO and AgNO in the wipe was demonstrated by SEM and XRD. In-vivo dermal decontamination efficacy of the prepared deconwipe was evaluated against nerve agent simulant (diethylchlorophosphate; DCP) and sulfur mustard simulant (2‑chloroethyl ethyl sulfide; CEES) on rat model using SEM, Flow Cytometry, Comet Acetylcholinesterase (AChE) inhibition assay and Organ Histopathology. In-vitro antibacterial and antifungal efficacy of the prepared deconwipe was evaluated using growth inhibitory efficacy techniques followed by SEM analysis. SEM and histopathology at dermal level revealed the decontamination efficacy of the prepared deconwipe. Nearly 90% decrease in AChE inhibition was observed in decontaminated rat in place of rate model as compared to the DCP contaminated rats. No significant attenuation was observed in DCP and CEES-induced cell cycle distribution and DNA damage analysis in decontaminated group. Furthermore, >95% inhibition of bacterial and fungal growth, proved its antibacterial and antifungal activity respectively. Thus, prepared deconwipes exhibit promising skin decontamination property against Chemical and biological contaminants.

DOI 10.1016/j.msec.2018.10.056
ISSN 1873-0191
Citation Sharma N, Chaudhary M, Butola BS, Jeyabalaji JK, Pathak DP, Sharma RK. Preparation, characterization and evaluation of the zinc titanate and silver nitrate incorporated wipes for topical chemical and biological decontamination. Mater Sci Eng C Mater Biol Appl. 2019;96:183-196.

Related Applications, Forms & Industries