Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor.

Author(s) Jure, I.; De Nicola, A.F.; Labombarda, F.
Journal Neural Regen Res
Date Published 2019 Dec
Abstract

A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone's mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone's direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.

DOI 10.4103/1673-5374.262570
ISSN 1673-5374
Citation Jure I, De Nicola AF, Labombarda F. Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor. Neural Regen Res. 2019;14(12):2029-2034.