Proton-induced production and radiochemical isolation of (44)Ti from scandium metal targets for (44)Ti/(44)Sc generator development.

Author(s) Radchenko, V.; Engle, J.W.; Medvedev, D.G.; Maassen, J.M.; Naranjo, C.M.; Unc, G.A.; Meyer, C.A.L.; Mastren, T.; Brugh, M.; Mausner, L.; Cutler, C.S.; Birnbaum, E.R.; John, K.D.; Nortier, M.; Fassbender, M.E.
Journal Nucl Med Biol
Date Published 2017 Jul

Scandium-44g (half-life 3.97h) shows promise for application in positron emission tomography (PET), due to favorable decay parameters. One of the sources of (44g)Sc is the (44)Ti/(44g)Sc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial (44)Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for (44)Ti isolation and purification. This study describes the production of a combined 175MBq (4.7mCi) batch yield of (44)Ti in week long proton irradiations at the Los Alamos Isotope Production Facility (LANL-IPF) and the Brookhaven Linac Isotope Producer (BNL-BLIP). A two-step ion exchange chromatography based chemical separation method is introduced: first, a coarse separation of (44)Ti via anion exchange sorption in concentrated HCl results in a (44)Tc/Sc separation factor of 10(2)-10(3). A second, cation exchange based step in HCl media is then applied for (44)Ti fine purification from residual Sc mass. In summary, this method yields a 90-97% (44)Ti recovery with an overall Ti/Sc separation factor of ≥10(6).

DOI 10.1016/j.nucmedbio.2017.03.006
ISSN 1872-9614
Citation Nucl Med Biol. 2017;50:2532.

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