Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications.

Author(s) Kumar, S.; Meena, V.Kumar; Hazari, P.Panwar; Sharma, S.Kumar; Sharma, R.Kumar
Journal Eur J Pharm Sci
Date Published 2018 May 30

We report here, reverse micelle mediated synthesis of multifunctional dextran (dex) coated GdO nanoparticles (NPs) carrying rose bengal (RB) dye for magnetic resonance and optical imaging. The diameter of these RB attached dex coated GdO NPs (Gd-dex-RB NPs) was found to be ~17 nm as measured by TEM. NMR line broadening effect on the surrounding water protons affirmed the paramagnetic nature of these NPs. Optical properties of Gd-dex-RB NPs were validated by UV-Vis and fluorescence spectroscopy. Time dependent release profile of RB from NPs at two different pH of 7.4 and 5.0 revealed that these NPs behave as slow releasing system. In-vitro study revealed that NPs are efficiently taken up by cells and show optical activity in cellular environment. In vitro cell viability (SRB) assay was performed on cancerous (A-549, U-87) and normal (HEK-293) cell lines, showed the absence of cytotoxic effect of Gd-dex-RB NPs. Therefore, such multifunctional NPs can be efficiently used for bio-imaging and optical tracking.

DOI 10.1016/j.ejps.2018.03.008
ISSN 1879-0720
Citation Eur J Pharm Sci. 2018;117:362370.

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