Surface modification of luminescent Ln(III) fluoride core-shell nanoparticles with acetyl salicylic acid (aspirin) - synthesis, spectroscopic and in vitro hemocompatibility studies.

Author(s) Kwiatek, D.; Mrówczyńska, L.Mrówczyns; Stopikowska, N.; Runowski, M.; Lesicki, A.; Lis, S.
Journal ChemMedChem
Date Published 2020 Jun 08

Luminescent lanthanide fluoride core-shell (LaF3:Tb3+,Ce3+@SiO2-NH2) nanoparticles, with acetyl salicylic acid (aspirin) coated on the surface were obtained. The synthesized products, combining the potential located in the silica shell with the luminescent activity of the core, were characterized in detail with the use of luminescence spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM) methods. The in vitro effects of the modified luminescent nanoparticles on human red blood cell (RBC) membrane permeability, RBC shape, and sedimentation rate, were investigated to assess the hemocompatibility of the obtained compounds. This study demonstrates that the LaF3: Tb3+ 5%, Ce3+ 10%@SiO2-NH2 nanoparticles with acetyl salicylic acid (aspirin) coated on the surface, are very good precursors for multifunctional drug-delivery systems or bio-imaging probe, which can be used safely in potential biomedical applications.

DOI 10.1002/cmdc.202000269
ISSN 1860-7187
Citation ChemMedChem. 2020.

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