Synthesis, functionalization and properties of uniform europium-doped sodium lanthanum tungstate and molybdate (NaLa(XO), X = Mo,W) probes for luminescent and X-ray computed tomography bioimaging.

Author(s) Laguna, M.; Nuñez, N.O.; Becerro, A.I.; Lozano, G.; Moros, M.; de la Fuente, J.M.; Corral, A.; Balcerzyk, M.; Ocaña, M.
Journal J Colloid Interface Sci
Date Published 2019 Jul 13

A one-pot simple procedure for the synthesis of uniform, ellipsoidal Eu-doped sodium lanthanum tungstate and molybdate (NaLa(XO), X  = W, Mo) nanophosphors, functionalized with carboxylate groups, is described. The method is based on a homogeneous precipitation process at 120 °C from appropriate Na, Ln and tungstate or molybdate precursors dissolved in ethylene glycol/water mixtures containing polyacrylic acid. A comparative study of the luminescent properties of both luminescent materials as a function of the Eu doping level has been performed to find the optimum nanophosphor, whose efficiency as X-ray computed tomography contrast agent is also evaluated and compared with that of a commercial probe. Finally, the cell viability and colloidal stability in physiological pH medium of the optimum samples have also been studied to assess their suitability for biomedical applications.

DOI 10.1016/j.jcis.2019.07.031
ISSN 1095-7103
Citation J Colloid Interface Sci. 2019;554:520530.

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