Synthesis of silver nanoparticles (AgNPs) from leaf extract of and its anticancer potential in human prostate cancer LNCaP cell lines.

Author(s) Zhang, K.; Liu, X.; Ravi, S.Oliver Abr; Ramachandran, A.; Ibrahim, I.Abdel Aziz; Nassir, A.M.; Yao, J.
Journal Artif Cells Nanomed Biotechnol
Date Published 2019 Dec
Abstract

Biosynthesis of silver nanoparticles (AgNPs) from the medicinal plants has been considered as a remarkable approach of several therapeutic innovations and successful drug delivery. Silver nanoparticles were biosynthesized with Chinese medicinal herb and assessed for its anticarcinogenic property. Synthesis of AgNPs was characterized by several studies such as UV-absorbance and it shows peak values in the range of 425-445 nm. The sizes of the nanoparticles are confirmed by dynamic light scattering analysis and it shows 100 nm. Furthermore, transmission electron microscopy (TEM) and energy dispersive X-ray analysis (EDX) was to confirm the shape and Ag particles are present in the synthesized materials. FTIR analysis to find out the active biomolecules located in the surface of the synthesized particles. This AgNPs from inhibits the growth of and . Furthermore, the anticancer potential of AgNPs is examined in prostate adenocarcinoma (LNCaP) cell lines. In this study, we found the AgNPs effectively induces cytotoxicity, ROS and apoptosis by modulation of intrinsic apoptoic Bcl2, Bclxl, Bax and Caspase 3 protein expressions in LNCap cell lines. Based on the study, synthesis of AgNPs from shows eco-friendly and it exhibits antimicrobial and anticarcinogenic effects.

DOI 10.1080/21691401.2019.1638792
ISSN 2169-141X
Citation Zhang K, Liu X, Ravi SO, Ramachandran A, Ibrahim IA, Nassir AM, et al. Synthesis of silver nanoparticles (AgNPs) from leaf extract of and its anticancer potential in human prostate cancer LNCaP cell lines. Artif Cells Nanomed Biotechnol. 2019;47(1):2846-2854.

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