Yolk @ cage-Shell Hollow Mesoporous Monodispersion Nanospheres of Amorphous Calcium Phosphate for Drug Delivery with High Loading Capacity.

Author(s) Huang, S.; Li, C.; Xiao, Q.
Journal Nanoscale Res Lett
Date Published 2017 Dec
Abstract

In this paper, yolk-shell hollow nanospheres of amorphous calcium phosphate (ACP) are prepared, and its loading capacity is investigated by comparing with that of solid-shell hollow structure ACP and cage-shell hollow structure ACP. Results show that the products are yolk @ cage-shell of ACP with large shell's pores size (15-40 nm) and large cavity volume. Adsorption results show that the loading capacity of yolk @ cage-shell hollow spherical ACP is very high, which is more than twice that of hollow ACP and 1.5 times of cage-like ACP. The main reasons are that the big shell's pore size contributes the large molecular doxorubicin hydrochloride (DOX · HCl) to enter the inner of hollow spheres easier, and the yolk-shell structure provides larger interior space and more adsorption sites for loading drugs.

DOI 10.1186/s11671-017-2051-7
ISSN 1931-7573
Citation Huang S, Li C, Xiao Q. Yolk @ cage-Shell Hollow Mesoporous Monodispersion Nanospheres of Amorphous Calcium Phosphate for Drug Delivery with High Loading Capacity. Nanoscale Res Lett. 2017;12(1):275.

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