CAS #:

Linear Formula:


MDL Number:


EC No.:



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cis-Diamminedichloroplatinum Properties (Theoretical)

Compound Formula Cl2H6N2Pt
Molecular Weight 300.05104
Appearance yellow crystals
Melting Point 270 °C
Boiling Point N/A
Density N/A
Solubility in H2O N/A
Exact Mass 298.955595
Monoisotopic Mass 298.955595

cis-Diamminedichloroplatinum Health & Safety Information

Signal Word Danger
Hazard Statements H300-H318-H350
Hazard Codes T
Risk Codes 45-25-41
Safety Statements 53-26-39-45
RTECS Number TP2450000
Transport Information UN 3288 6.1/PG II
WGK Germany 3
GHS Pictograms

View and Print SDS


Date Accessed: 08/16/2022
Date Revised: 05/15/2015


Product Name: cis-Diamminedichloroplatinum

Product Number: All applicable American Elements product codes, e.g. PT-MACL-01

CAS #: 15663-27-1

Relevant identified uses of the substance: Scientific research and development

Supplier details:
American Elements
10884 Weyburn Ave.
Los Angeles, CA 90024
Tel: +1 310-208-0551
Fax: +1 310-208-0351

Emergency telephone number:
Domestic, North America: +1 800-424-9300
International: +1 703-527-3887


Classification of the substance or mixture in accordance with 29 CFR 1910 (OSHA HCS)
GHS06 Skull and crossbones
Acute Tox. 2 H300 Fatal if swallowed.
GHS08 Health hazard
Resp. Sens. 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Carc. 1B H350 May cause cancer.
Skin Irrit. 2 H315 Causes skin irritation.
Eye Irrit. 2A H319 Causes serious eye irritation.
Skin Sens. 1 H317 May cause an allergic skin reaction.
STOT SE 3 H335 May cause respiratory irritation.
Hazards not otherwise classified No data available
GHS label elements, including precautionary statements

Skull and Crossbones - GHS06Health Hazard - GHS08 Exclamation Mark - GHS07

Hazard pictograms
Signal word Danger
Hazard statements
H300 Fatal if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H317 May cause an allergic skin reaction.
H350 May cause cancer.
H335 May cause respiratory irritation.
Precautionary statements
P201 Obtain special instructions before use.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor
P308+P313 IF exposed or concerned: Get medical advice/attention.
WHMIS classification
D1A - Very toxic material causing immediate and serious toxic effects
D2A - Very toxic material causing other toxic effects
Classification system
HMIS ratings (scale 0-4)
(Hazardous Materials Identification System)

Health (acute effects) = 3
Flammability = 0
Physical Hazard = 1
Other hazards
Results of PBT and vPvB assessment
vPvB: N/A


CAS No. / Substance Name:
15663-27-1 cis-Diamminedichloroplatinum(II)
Identification number(s):
EC number: 239-733-8


Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
In case of irregular breathing or respiratory arrest provide artificial respiration.
If inhaled:
Supply patient with fresh air. If not breathing, provide artificial respiration. Keep patient warm.
Seek immediate medical advice.
In case of skin contact:
Immediately wash with soap and water; rinse thoroughly.
Seek immediate medical advice.
In case of eye contact:
Rinse opened eye for several minutes under running water. Consult a physician.
If swallowed:
Do not induce vomiting; immediately call for medical help.
Information for doctor
Most important symptoms and effects, both acute and delayed:
No data available
Platinum compounds, especially platinum halogen complexes, are sensitizers. Sensitized persons, on re-exposure to platinum salts, will show the clinical features of
a Type 1 allergy: asthma and/or rhinitis and/or conjunctivitis and/or urticaria. A contact dermatitis may also occur. The symptoms of the allergic reaction to platinum
salts may include any of the following: itchy red eyes, watering of the eyes, sneezing, runny nose, chest tightness, wheezing, breathlessness, cough, eczematous or
urticarial (nettle rash type) skin lesions. Exposure to platinum salts in exceedingly small amounts, even below the level of
physico-chemical detection, will produce symptoms in sensitized persons. Continued exposure will give symptoms of increasing severity and can eventually lead to
chronic asthma. There is a risk of anaphylactic shock occuring in sensitized persons re-encountering platinum salts. Therefore, if sensitization has developed, further
exposure to platinum compounds must not be permitted.
Indication of any immediate medical attention and special treatment needed:
No data available


Extinguishing media
Suitable extinguishing agents Product is not flammable. Use fire-fighting measures that suit the surrounding fire.
Special hazards arising from the substance or mixture
If this product is involved in a fire, the following can be released:
Hydrogen chloride (HCl)
Nitrogen oxides (NOx)
Advice for firefighters
Protective equipment:
Wear self-contained respirator.
Wear fully protective impervious suit.


Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Keep unprotected persons away.
Ensure adequate ventilation
Environmental precautions: Do not allow material to be released to the environment without official permits.
Methods and materials for containment and cleanup:
Dispose of contaminated material as waste according to section 13.
Ensure adequate ventilation.
Prevention of secondary hazards: No special measures required.
Reference to other sections
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.


Precautions for safe handling
Keep container tightly sealed.
Store in cool, dry place in tightly closed containers.
Ensure good ventilation at the workplace.
Open and handle container with care.
Information about protection against explosions and fires: The product is not flammable
Conditions for safe storage, including any incompatibilities
Requirements to be met by storerooms and receptacles: No special requirements.
Information about storage in one common storage facility: Store away from oxidizing agents.
Further information about storage conditions:
Keep container tightly sealed.
Store in cool, dry conditions in well-sealed containers.
Specific end use(s) No data available


Additional information about design of technical systems:
Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute.
Control parameters
Components with limit values that require monitoring at the workplace:
Platinum metal and soluble salts (as Pt)
ACGIH TLV 1 (metal); 0.002 (soluble salts)
Austria MAK 1 (metal); 0.002 (soluble salts)
Belgium TWA 1 (metal); 0.002 (soluble salts)
Denmark TWA 0.002 (soluble salts)
Finland TWA 1 (metal); 0.002 (soluble salts)
France VME 1 (metal)
Germany MAK 0.002 (soluble salts)-Ceiling
Hungary TWA 0.001; 0.002-STEL (soluble salts)
Korea TLV 1 (metal); 0.002 (soluble salts)
Netherlands MAC-TTG 1 (metal); 0.002 (soluble salts)
Norway TWA 0.002
Switzerland MAK-W 0.002
United Kingdom TWA 5 (metal); 0.002 (soluble salts)
USA PEL 0.002
15663-27-1 cis-Diamminedichloroplatinum(II) (100.0%)
PEL (USA) Long-term value: 0.002 mg/m3
as Pt
REL (USA) Long-term value: 0.002 mg/m3
as Pt
TLV (USA) Long-term value: 0.002 mg/m3
as Pt
EL (Canada) Long-term value: 0.002 mg/m3
as Pt; S
Additional information: No data
Exposure controls
Personal protective equipment
Follow typical protective and hygienic practices for handling chemicals.
Keep away from foodstuffs, beverages and feed.
Remove all soiled and contaminated clothing immediately.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
Maintain an ergonomically appropriate working environment.
Breathing equipment: Use suitable respirator when high concentrations are present.
Protection of hands:
Impervious gloves
Inspect gloves prior to use.
The selection of suitable gloves not only depends on the material, but also on quality. Quality will vary from manufacturer to manufacturer.
Eye protection: Safety glasses
Body protection: Protective work clothing.


Information on basic physical and chemical properties
Form: Crystalline
Color: Yellow
Odor: Odorless
Odor threshold: Not determined.
pH: N/A
Melting point/Melting range: 270 °C (518 °F) (dec)
Boiling point/Boiling range: Not determined
Sublimation temperature / start: Not determined
Flash point: N/A
Flammability (solid, gas) Not determined.
Ignition temperature: Not determined
Decomposition temperature: Not determined
Autoignition: Not determined.
Danger of explosion: Product does not present an explosion hazard.
Explosion limits:
Lower: Not determined
Upper: Not determined
Vapor pressure: N/A
Density: Not determined
Relative density Not determined.
Vapor density N/A
Evaporation rate N/A
Solubility in / Miscibility with
Water at 20 °C (68 °F): 2.53 g/l
Partition coefficient (n-octanol/water): Not determined.
Dynamic: N/A
Kinematic: N/A
Other information No data available


Reactivity No data available
Chemical stability Stable under recommended storage conditions.
Thermal decomposition / conditions to be avoided: Decomposition will not occur if used and stored according to specifications.
Possibility of hazardous reactions No dangerous reactions known
Conditions to avoid No data available
Incompatible materials: Oxidizing agents
Hazardous decomposition products:
Hydrogen chloride (HCl)
Nitrogen oxides (NOx)


Information on toxicological effects
Acute toxicity: Fatal if swallowed.
LD/LC50 values that are relevant for classification: No data
Skin irritation or corrosion: Causes skin irritation.
Eye irritation or corrosion: Causes serious eye irritation.
Platinum salts, especially ionic platinum halogeno complexes, may cause severe allergic reactions.
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause an allergic skin reaction.
Germ cell mutagenicity: No effects known.
May cause cancer.
NTP-R: Reasonably anticipated to be a carcinogen: limited evidence from studies in humans or sufficient evidence from studies in experimental animals.
IARC-2A: Probably carcinogenic to humans: limited human evidence; sufficient evidence in experimental animals
The Registry of Toxic Effects of Chemical Substances (RTECS) contains tumorigenic and/or carcinogenic and/or neoplastic data for this substance.
Reproductive toxicity: No effects known.
Specific target organ system toxicity - repeated exposure: No effects known.
Specific target organ system toxicity - single exposure: May cause respiratory irritation.
Aspiration hazard: No effects known.
Other information (about experimental toxicology):
Tumorigenic effects have been observed on tests with laboratory animals.
Mutagenic effects have been observed on tests with bacteria.
Reproductive effects have been observed on tests with laboratory animals.
Subacute to chronic toxicity:
Exposure to platinum containing dusts or fumes may cause irritation, sensitization reactions and asthma. Effects include sneezing, coughing, tightness in the chest,
dyspnea and wheezing. Cyanosis is possible. Chronic exposure may result in pulmonary fibrosis.
Subacute to chronic toxicity: No effects known.
Subacute to chronic toxicity:
Exposure to cis-diaminedichloroplatinum (II) causes damage to the kidneys, bone marrow, ears, liver, blood, peripheral nervous system, testes and female
reproductive system. RTECS cites reproductive, tumorigenic and carcinogenic effects in laboratory animals.
Additional toxicological information: To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.


Aquatic toxicity: No data available
Persistence and degradability No data available
Bioaccumulative potential No data available
Mobility in soil No data available
Additional ecological information:
Do not allow material to be released to the environment without official permits.
Do not allow product to reach groundwater, water courses, or sewage systems, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
Avoid transfer into the environment.
Results of PBT and vPvB assessment
vPvB: N/A
Other adverse effects No data available


Waste treatment methods
Recommendation Consult official regulations to ensure proper disposal.
Uncleaned packagings:
Recommendation: Disposal must be made according to official regulations.


UN proper shipping name
DOT Toxic solid, inorganic, n.o.s. (cis-Diamminedichloroplatinum(II))
IMDG, IATA TOXIC SOLID, INORGANIC, N.O.S. (cis-Diamminedichloroplatinum(II))
Transport hazard class(es)
Class 6.1 Toxic substances.
Label 6.1
Class 6.1 (T5) Toxic substances
Label 6.1
Class 6.1 Toxic substances.
Label 6.1
Packing group
Environmental hazards: N/A
Special precautions for user Warning: Toxic substances
EMS Number: F-A,S-A
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code N/A
Transport/Additional information:
Marine Pollutant (DOT): No
UN "Model Regulation": UN3288, Toxic solid, inorganic, n.o.s. (cis-Diamminedichloroplatinum(II)), 6.1, II


Safety, health and environmental regulations/legislation specific for the substance or mixture
GHS label elements, including precautionary statements
Hazard pictograms
Signal word Danger
Hazard statements
H300 Fatal if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H317 May cause an allergic skin reaction.
H350 May cause cancer.
H335 May cause respiratory irritation.
Precautionary statements
P201 Obtain special instructions before use.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor
P308+P313 IF exposed or concerned: Get medical advice/attention.
National regulations
All components of this product are listed in the U.S. Environmental Protection Agency Toxic Substances Control Act Chemical substance Inventory.
All components of this product are listed on the Canadian Non-Domestic Substances List (NDSL).
SARA Section 313 (specific toxic chemical listings) Substance is not listed.
California Proposition 65
Prop 65 - Chemicals known to cause cancer
15663-27-1 cis-Diamminedichloroplatinum(II)
Prop 65 - Developmental toxicity Substance is not listed.
Prop 65 - Developmental toxicity, female Substance is not listed.
Prop 65 - Developmental toxicity, male Substance is not listed.
Information about limitation of use:
Workers are not allowed to be exposed to this hazardous material. Exceptions can be made by the authorities in certain cases.
For use only by technically qualified individuals.
Other regulations, limitations and prohibitive regulations
Substance of Very High Concern (SVHC) according to the REACH Regulations (EC) No. 1907/2006. Substance is not listed.
The conditions of restrictions according to Article 67 and Annex XVII of the Regulation (EC) No 1907/2006 (REACH) for the manufacturing, placing on the
market and use must be observed.
Substance is not listed.
Annex XIV of the REACH Regulations (requiring Authorisation for use) Substance is not listed.
Chemical safety assessment: A Chemical Safety Assessment has not been carried out.


Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH). The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. American Elements shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. COPYRIGHT 1997-2022 AMERICAN ELEMENTS. LICENSED GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY.

About cis-Diamminedichloroplatinum

Cisplatin (cis-Diamminedichloroplatinum) is a organometallic compound and one of several platinum-based antineoplastic agents used in certain types of chemotherapy for the treatment of cancer. These compounds, also known as platins, include Oxaliplatin, Nedaplatin, Carboplatin, Satraplatin, and Miboplatin. Please note that this material is for research purposes only and not intended for human use. American Elements supplies all organometallic products in most volumes including bulk quantities and also can produce materials to customer specifications. Please request a quote above for more information on pricing and lead time.

cis-Diamminedichloroplatinum Synonyms

cis-Dichlorodiammine platinum(II), trans-Platinum(II)diammine dichloride, Cisplatin, (SP-4-2)-diamminedichloroplatinum(II), Platinum acetate blue, PAB, cisplatinum, platamin, neoplatin, cismaplat, CDDP, NSC 119875

Chemical Identifiers

Linear Formula Pt(NH3)2Cl2
MDL Number MFCD00011623
EC No. 239-733-8
Beilstein/Reaxys No. N/A
Pubchem CID 5702198
IUPAC Name azane; dichloroplatinum
InchI Identifier InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

Packaging Specifications

Typical bulk packaging includes palletized plastic 5 gallon/25 kg. pails, fiber and steel drums to 1 ton super sacks in full container (FCL) or truck load (T/L) quantities. Research and sample quantities and hygroscopic, oxidizing or other air sensitive materials may be packaged under argon or vacuum. Shipping documentation includes a Certificate of Analysis and Safety Data Sheet (SDS). Solutions are packaged in polypropylene, plastic or glass jars up to palletized 440 gallon liquid totes, and 36,000 lb. tanker trucks.

Related Elements


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See more Nitrogen products. Nitrogen is a Block P, Group 15, Period 2 element. Its electron configuration is [He]2s22p3. Nitrogen is an odorless, tasteless, colorless and mostly inert gas. It is the seventh most abundant element in the universe and it constitutes 78.09% (by volume) of Earth's atmosphere. Nitrogen was discovered by Daniel Rutherford in 1772.


See more Platinum products. Platinum (atomic symbol: Pt, atomic number: 78) is a Block D, Group 10, Period 6 element with an atomic weight of 195.084. The number of electrons in each of platinum's shells is [2, 8, 18, 32, 17, 1] and its electron configuration is [Xe] 4f14 5d9 6s1. The platinum atom has a radius of 139 pm and a Van der Waals radius of 175 pm. Platinum Bohr ModelElemental PlatinumPlatinum was discovered and first isolated by Antonio de Ulloa in 1735. It is one of the rarest elements in the earth's crust, occurring at a concentration of only 0.005 ppm. Platinum is found uncombined as a free element and alloyed with iridium as platiniridium. In its elemental form, platinum has a grayish white appearance. It is highly resistant to corrosion: the metal does not oxidize in air at any temperature. It is generally non-reactive, even at high temperatures. The origin of the name "platinum" comes from the Spanish word platina, meaning silver.


August 16, 2022
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